CHA 의과학대학교 분당차병원 임상시험센터

핵심인력

안과 질환 연구팀

안과질환 연구팀(안재생시각연구소)의 주된 연구분야는 안과질환에 대한 줄기세포 치료효과 및 기작에 관한 연구를 진행하고 있습니다.
· 시신경 손상 쥐에서 태반줄기세포의 치료효과
· 태반줄기세포를 이용한 갑상선 안질환에서 세포치료제 개발

MEMBER

상세소개

유혜린 교수

· 소속
안과
· 연구분야
사시와약시, 안성형 외

상세소개

이동율 교수

· 소속
의생명과학과
· 연구분야
체세포 핵 치환(Somatic-cell nuclear transfer, SCNT), 배아줄기세포, 성체줄기세포

상세소개

김기진 교수

· 소속
의생명과학과
· 연구분야
암세포 유전학

박미라 연구원

· 소속
안과
· 연구분야
안과 질환

Major Research Fields

  • 갑상샘안질환, 시신경병증, 성형안과
  • 나이관련 황반변성, 유전성 황반 이영양증,
    다분화 줄기세포치료
  • 배아의 초기발생과정, 배아줄기세포 및
    정원줄기세포의 확립 및 분화
  • 의약생명공학 ,암세포유전학

Publication

  • 1. Human placenta mesenchymal stem cells promote axon survival following optic nerve compression through activation of NF-𝜅B pathway.

    Park M, Kim HC, Kim O, Lew H.
    J Tissue Eng Regen Med. 2017 Aug 31. doi: 10.1002/term.2561. [Epub ahead of print]

  • 2. Customized Orbital Decompression Surgery Combined with Eyelid Surgery or Strabismus Surgery in Mild to Moderate Thyroid-associated Ophthalmopathy.

    Choi SW, Lee JY, Lew H
    Korean J Ophthalmol. 2016 Feb;30(1):1-9. doi: 10.3341/kjo.2016.30.1.1. Epub 2016 Jan 21.

  • 3. Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury.

    Chung S, Rho S, Kim G, Kim SR, Baek KH, Kang M, Lew H.
    Int J Mol Med. 2016 May;37(5):1170-80. doi: 10.3892/ijmm.2016.2532. Epub 2016 Mar 17.

  • 4. Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and susceptibility to Graves' ophthalmopathy.

    Lee JY, Kim NK, Cho YW, Lew H.
    Mol Med Rep. 2016 Sep;14(3):2276-82. doi: 10.3892/mmr.2016.5458. Epub 2016 Jun 30.

  • 5. Clinical Outcomes of Frontalis Sling Using Silicone Rod With Two-point Brow Incisions in Blepharoptosis.

    Sung Y, Park JS, Lew H.
    J Pediatr Ophthalmol Strabismus. 2016 Jul 1;53(4):224-32. doi: 10.3928/01913913-20160511-04.

  • 6. Measurement of lacrimal punctum using spectralis domain anterior optical coherence tomography.

    Sung Y, Park JS, Lew H.
    Acta Ophthalmol. 2016 Dec 28. doi: 10.1111/aos.13322. [Epub ahead of print]

  • 7. Blepharoplasty with a Buried Double Twisted Suture Technique to Correct Upper Eyelid Epiblepharon.

    Choi SW, Goldberg RA, Lew H.
    Plast Reconstr Surg Glob Open. 2016 Apr 21;4(4):e685. doi: 10.1097/GOX.0000000000000667.

  • 8. Three-dimensional printing using open source software and JPEG images from optical coherence tomography of an epiretinal membrane patient.

    Choi SW, Kwon HJ, Song WK.
    Acta Ophthalmol. 2016 Nov 22. doi: 10.1111/aos.13179. [Epub ahead of print]

  • 9. An efficient SCNT technology for the establishment of personalized and public human pluripotent stem cell banks.

    Lee JE, Chung YG, Eum JH, Lee Y, Lee DR.
    BMB Rep. 2016 Apr;49(4):197-8.

  • 10. RuvB-Like Protein 2 (Ruvbl2) Has a Role in Directing the Neuroectodermal Differentiation of Mouse Embryonic Stem Cells.

    Hong S, Jo J, Kim HJ, Lee JE, Shin DH, Lee SG, Baek A, Shim SH, Lee DR.
    Stem Cells Dev. 2016 Sep 15;25(18):1376-85. doi: 10.1089/scd.2016.0076. Epub 2016 Aug 30.

  • 11. Supplementation With Cell-Penetrating Peptide-Conjugated Estrogen-Related Receptor β Improves the Formation of the Inner Cell Mass and the Development of Vitrified/Warmed Mouse Embryos.

    Yang NJ, Seol DW, Jo J, Jang HM, Yoon SY, Lee WS, Lee DR.
    Reprod Sci. 2016 Nov;23(11):1509-1517. Epub 2016 Apr 12.

  • 12. An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency.

    Jo J, Hwang S, Kim HJ, Hong S, Lee JE, Lee SG, Baek A, Han H, Lee JI, Lee I, Lee DR.
    Nucleic Acids Res. 2016 Feb 18;44(3):1203-15. doi: 10.1093/nar/gkv1468. Epub 2016 Jan 5.

  • 13. Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway.

    Lim SM, Jang HY, Lee JE, Shin JS, Park SH, Yoon BH, Kim GJ.
    PLoS One. 2016 Feb 22;11(2):e0149371. doi: 10.1371/journal.pone.0149371. eCollection 2016.

  • 14. Aberrant expression of plasma microRNA-33a in an atherosclerosis-risk group.

    Kim SH, Kim GJ, Umemura T, Lee SG, Cho KJ.
    Mol Biol Rep. 2017 Feb;44(1):79-88. doi: 10.1007/s11033-016-4082-z. Epub 2016 Sep 23.

  • 15. Usefulness of the ratio of orbital fat to total orbit area in mild-to-moderate thyroid-associated ophthalmopathy.

    Kim HC, Yoon SW, Lew H.
    Br J Radiol. 2015 Sep;88(1053):20150164. doi: 10.1259/bjr.20150164. Epub 2015 Jul 7.

  • 16. Possible linkage between visual and motor development in children with cerebral palsy.

    Lew H, Lee HS, Lee JY, Song J, Min K, Kim M.
    Pediatr Neurol. 2015 Mar;52(3):338-43.e1. doi: 10.1016/j.pediatrneurol.2014.11.009. Epub 2014 Dec 3.

  • 17. Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients.

    Song WK, Park KM, Kim HJ, Lee JH, Choi J, Chong SY, Shim SH, Del Priore LV, Lanza R.
    Stem Cell Reports. 2015 May 12;4(5):860-72. doi: 10.1016/j.stemcr.2015.04.005. Epub 2015 Apr 30.

  • 18. Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.

    Chung YG, Matoba S, Liu Y, Eum JH, Lu F, Jiang W, Lee JE, Sepilian V, Cha KY, Lee DR, Zhang Y.
    Cell Stem Cell. 2015 Dec 3;17(6):758-66. doi: 10.1016/j.stem.2015.10.001. Epub 2015 Oct 29.

  • 19. Microenvironmental Interaction Between Hypoxia and Endothelial Cells Controls the Migration Ability of Placenta-Derived Mesenchymal Stem Cells via α4 Integrin and Rho Signaling.

    Choi JH, Lim SM, Yoo YI, Jung J, Park JW, Kim GJ.
    J Cell Biochem. 2016 May;117(5):1145-57. doi: 10.1002/jcb.25398. Epub 2015 Oct 18.

  • 20. Epigenetic Alterations of IL-6/STAT3 Signaling by Placental Stem Cells Promote Hepatic Regeneration in a Rat Model with CCl4-induced Liver Injury.

    Jung J, Moon JW, Choi JH, Lee YW, Park SH, Kim GJ.
    Int J Stem Cells. 2015 May;8(1):79-89. doi: 10.15283/ijsc.2015.8.1.79.

  • 21. Effect of mesenchymal stem cells and extracts derived from the placenta on trophoblast invasion and immune responses.

    Choi JH, Jung J, Na KH, Cho KJ, Yoon TK, Kim GJ.
    Stem Cells Dev. 2014 Jan 15;23(2):132-45. doi: 10.1089/scd.2012.0674. Epub 2013 Oct 19.

  • 22. Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells.

    Lee HJ, Choi JH, Jung J, Kim JK, Lee SS, Kim GJ.
    Cell Tissue Res. 2014 Jul;357(1):145-57. doi: 10.1007/s00441-014-1874-0. Epub 2014 May 11.

  • 23. Orbital volume augmentation after injection of human orbital adipose-derived stem cells in rabbits.

    Lee JY, Lee KH, Shin HM, Chung KH, Kim GI, Lew H.
    Invest Ophthalmol Vis Sci. 2013 Apr 1;54(4):2410-6. doi: 10.1167/iovs.12-11210.

  • 24. Tear production and drainage after botulinum toxin A injection in patients with essential blepharospasm.

    Park DI, Shin HM, Lee SY, Lew H.
    Acta Ophthalmol. 2013 Mar;91(2):e108-12. doi: 10.1111/aos.12002.

  • 25. Isolation and characterization of novel, highly proliferative human CD34/CD73-double-positive testis-derived stem cells for cell therapy.

    Choi WY, Jeon HG, Chung Y, Lim JJ, Shin DH, Kim JM, Ki BS, Song SH, Choi SJ, Park KH, Shim SH, Moon J, Jung SJ, Kang HM, Park S, Chung HM, Ko JJ, Cha KY, Yoon TK, Kim H, Lee DR.
    Stem Cells Dev. 2013 Aug 1;22(15):2158-73. doi: 10.1089/scd.2012.0385. Epub 2013 May 3.

  • 26. DNA fragmentation of human sperm can be detected by ligation-mediated real-time polymerase chain reaction.

    Lim JJ, Lee JI, Kim DH, Song SH, Kim HJ, Lee WS, Lee DR.
    Fertil Steril. 2013 Dec;100(6):1564-71.e1-5. doi: 10.1016/j.fertnstert.2013.08.017. Epub 2013 Sep 11.

  • 27. Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4 -injured rat liver model via increased autophagic mechanism.

    Jung J, Choi JH, Lee Y, Park JW, Oh IH, Hwang SG, Kim KS, Kim GJ.
    Stem Cells. 2013 Aug;31(8):1584-96. doi: 10.1002/stem.1396.

  • 28. Korean mistletoe lectin promotes proliferation and invasion of trophoblast cells through regulation of Akt signaling.

    Lyu SY, Choi JH, Lee HJ, Park WB, Kim GJ.
    Reprod Toxicol. 2013 Aug;39:33-9. doi: 10.1016/j.reprotox.2013.03.011. Epub 2013 Apr 6.

  • 29. Increased SCF/c-kit by hypoxia promotes autophagy of human placental chorionic plate-derived mesenchymal stem cells via regulating the phosphorylation of mTOR.

    Lee Y, Jung J, Cho KJ, Lee SK, Park JW, Oh IH, Kim GJ.
    J Cell Biochem. 2013 Jan;114(1):79-88. doi: 10.1002/jcb.24303.

  • 30. Hypoxia-induced downregulation of XIAP in trophoblasts mediates apoptosis via interaction with IMUP-2: implications for placental development during pre-eclampsia.

    Jeon SY, Lee HJ, Na KH, Cha DH, Kim JK, Park JW, Yoon TK, Kim GJ.
    J Cell Biochem. 2013 Jan;114(1):89-98. doi: 10.1002/jcb.24304.

  • 31. Efficacy of chorionic plate-derived mesenchymal stem cells isolated from placenta in CCl4-injured rat liver depends on transplantation routes

    Jung JE, Na KH, Lee MJ, Moon JS, Kim GI, Jang JJ, Hwang SG, Kim GJ.
    Tissue Engineering and Regenerative Medicine. Vol. 10, No. 1, pp 10-17 (2013).DOI 10.1007/s13770-013-0364-x
논문 더보기+
top
CellTheP 세포치료제 R&BD 지원센터경기도 성남시 분당구 판교로 335 차바이오컴플렉스
COPYRIGHT (C) 2017 CHAMC. ALL RIGHTS RESERVED.