뇌신경계 질환

뇌신경계 질환 연구팀

뇌졸중(뇌경색, 뇌출혈), 치매, 저산소증 등 다양한 신경계 질환에 대한 기초 연구(in vivo/in vitro검사), 중개 연구, 이를 바탕으로 줄기세포 임상연구(뇌졸중, 치매 타가유래 중간엽 줄기세포 IV주사 치료) 를 현재 진행하고 있습니다.
임상적용이 가능한 줄기세포 기능 강화 연구를 현재 진행하고 있으며, 유전자 변이 줄기세포 등 다양한 줄기세포 연구도 활발히 진행되고 있습니다.
또한, 각종 뇌졸중 연관 유전자 발굴 및 관련 연구로 많은 SCI논문을 발표하고 있습니다.

MEMBER

상세소개

김옥준 교수

· 소속: 신경과

· 연구분야: 치매, 뇌전증(간질), 뇌졸중

상세소개

오승헌 교수

· 소속: 신경과

· 연구분야: 척추질환, 말초질환 외

상세소개

정태녕 교수

· 소속: 응급의학과

· 연구분야: 소생의학, 중환자의학 외

상세소개

김남근 교수

· 소속: 의생명과학과

· 연구분야: 분자유전학

상세소개

권민수 교수

· 소속: 약리학교실

· 연구분야: 뇌신경계질환,신경면역학

상세소개

김민영 교수

· 소속: 재활의학과

· 연구분야: 뇌졸중,소아재활

Major Research Fields

뇌졸중, 치매, 줄기세포, 신규 유전자 발굴
심폐 뇌 소생, 무산소성 뇌 손상, 줄기세포
뇌졸중, 분자유전학, 혈관/혈전 관련 인자

Publication

1. The Role of RNF213 4810G>A and 4950G>A Variants in Patients with Moyamoya Disease in Korea.
Park YS, An HJ, Kim JO, Kim WS, Han IB, Kim OJ, Kim NK, Kim DS.
Int J Mol Sci. 2017 Nov 21;18(11). pii: E2477. doi: 10.3390/ijms18112477

2. Effect of Adipose-Derived Mesenchymal Stem Cell Administration and Mild Hypothermia Induction on Delayed Neuronal Death After Transient Global Cerebral Ischemia.
Chung TN, Kim JH, Choi BY, Jeong JY, Chung SP, Kwon SW, Suh SW.
Crit Care Med. 2017; May;45(5):e508-e515.

3. Human placenta mesenchymal stem cells promote axon survival following optic nerve compression through activation of NF-𝜅B pathway.
Park M, Kim HC, Kim O, Lew H.
J Tissue Eng Regen Med. 2017 Aug 31. doi: 10.1002/term.2561. [Epub ahead of print]

4. Predictors of disclosure management behavior at the end of 1-year follow-up in Korean adults with newly diagnosed epilepsy.
Lee SA, No SK, Park H, Kim OJ, Kwon JH, Ryu JY, Lee SM, Jo KD.
Epilepsy Behav. 2017 Sep;74:94-98.

5. Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study.
Seo WK, Kim YJ, Lee J, Kwon SU; PICASSO Investigators.
J Stroke Cerebrovasc Dis. 2017 Sep;26(9):1892-1898.

6. Interplay between 3'-UTR polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk of ischemic stroke.
Kim JO, Park HS, Ryu CS, Shin JW, Kim J, Oh SH, Kim OJ, Kim NK.
Sci Rep. 2017 Sep 29;7(1):12464. doi: 10.1038/s41598-017-12668-x.

7. Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease.
Kim J, Yoon SJ, Woo MH, Kim SH, Kim NK, Kim J, Kim OJ, Oh SH.
PLoS One. 2017 Mar 20;12(3):e0173736. doi: 10.1371/journal.pone.0173736. eCollection 2017.

8. Redefining Periodic Patterns on Electroencephalograms of Patients with Sporadic Creutzfeldt-Jakob Disease
Shin JW, Yim BS, Oh SH, Kim OJ
Clinical Neurophysiology, February 2017 May;128(5):756-762.

9. Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality.
Kim J, Choi GH, Ko KH, Kim JO, Oh SH, Park YS, Kim OJ, Kim NK.
PLoS One. 2016 Sep 7;11(9):e0162519. doi: 10.1371/journal.pone.0162519.

10. Association of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.
Kim J, Choi GH, Ko KH, Kim JO, Oh SH, Park YS, Kim OJ, Kim NK.
PLoS One. 2016 Sep 7;11(9):e0162519. doi: 10.1371/journal.pone.0162519.

11. miRNA polymorphisms (miR‑146a, miR‑149, miR‑196a2 and miR‑499) are associated with the risk of coronary artery disease.
Sung JH, Kim SH, Yang WI, Kim WJ, Moon JY, Kim I J, Cha DH, Cho SY, Kim JO, Kim KA, Kim OJ, Lim SW, Kim NK.
Mol Med Rep. 2016 Sep;14(3):2328-42. doi: 10.3892/mmr.2016.5495.

12. Clinical Experience of Intra-Arterial Therapy in Patients with Acute Ischemic Stroke from a Single Institute
Park SY, Lee H, Kim J, Oh SH, Kim J, Kim NK, Kim SH, Kim OJ.
J Korean Soc Radiol. 2016 Nov;75(5):346-353.

13. Tube thoracostomy training with a medical simulator is associated with faster, more successful performance of the procedure.
Chung TN, Kim SW, You JS, Chung HS.
Clin Exp Emerg Med. 2016; Mar 31;3(1):16-19

14. Effect of the rate of chest compression familiarised in previous training on the depth of chest compression during metronome-guided cardiopulmonary resuscitation: a randomised crossover trial.
Bae J, Chung TN, Je SM.
BMJ open 2016; Feb 12;6(2):e010873.

15. Attenuation of Postischemic Genomic Alteration by Mesenchymal Stem Cells: a Microarray Study.
Choi C, Oh SH, Noh JE, Jeong YW, Kim S, Ko JJ, Kim OJ, Song J.
Mol Cells. 2016 Apr 30;39(4):337-44. doi: 10.14348/molcells.2016.2317.

16. Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction
Han SW, Song TJ, Bushnell CD, Lee SS, Kim SH, Lee JH, Kim GS, Kim OJ, Koh IS, Lee JY, Suk SH, Lee SI, Nam HS, Lee KY, Park JH
J Neuroimaging. 2016 May;26(3):351-4. doi: 10.1111/jon.12308. Epub 2015 Oct 13.

17. Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms wi th the risk of ischemic stroke.
Choi GH, Ko KH, Kim JO, Kim J, Oh SH, Han IB, Cho KG, Kim OJ, Bae J, Kim NK.
Int J Mol Med. 2016 Jul;38(1):345-56. doi: 10.3892/ijmm.2016.2609.

18. The Effect of Pulsatility Index on Infarct Volume in Acute Lacunar Stroke.
Kim Y, Lee H, An SA, Yim B, Kim J, Kim OJ, Kim WC, Kim HS, Oh SH, Kim J.
Yonsei Med J. 2016 Jul;57(4):950-5. doi: 10.3349/ymj.2016.57.4.950.

19 .Design and Rationale for a Cognitive Outcome Substudy in Ischemic Stroke Patients with High Risk of Cerebral Hemorrhage.
Yu KH, Hong KS, Oh MS, Lee J, Lee JS, Kwon SU; PICASSO investigators.
J Stroke Cerebrovasc Dis. 2016 Aug;25(8):2061-6.

20. Factors contributing to the development of perceived stigma in people with newly diagnosed epilepsy: A one-year longitudinal study.
Lee GH, Lee SA, No SK, Lee SM, Ryu JY, Jo KD, Kwon JH, Kim OJ, Park H, Kwon OY, Kim JH, Kim WJ.
Epilepsy Behav. 2016 Jan;54:1-6. doi: 10.1016/j.yebeh.2015.10.024. Epub 2015 Nov 25.

21. Red Blood Cell Distribution Width Is Associated with Severity of Leukoaraiosis.
Lee HB, Kim J, Oh SH, Kim SH, Kim HS, Kim WC, Kim S, Kim OJ.
PLoS One. 2016 Feb 26;11(2):e0150308. doi: 10.1371/journal.pone.0150308.

22. Association of knowledge about epilepsy with mood and self-efficacy in Korean people with epilepsy.
Lee SA, Lee BI; Korean QoL in Epilepsy Study Group..
Epilepsy Behav. 2015 Nov;52(Pt A):149-53. doi: 10.1016

23. The effect of recurrent seizures on cognitive, behavioral, and quality-of-life outcomes after 12months of monotherapy in adults with newly diagnosed or previously untreated partial epilepsy.
Lee SA, Kim MJ, Lee HW, Heo K, Shin DJ, Song HK, Kim OJ, Kim SO, Lee BI.
Epilepsy Behav. 2015 Dec;53:202-8. doi: 10.1016/j.yebeh.2015.10.020.

24. Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis.
Sung JH, Lee BE, Kim JO, Jeon YJ, Kim SH, Lim SW, Moon JY, Cha DH, Kim OJ, Kim IJ, Kim NK.
Genet Mol Res. 2015 Dec 9;14(4):16508-20.

25. Association between Serum Alkaline Phosphatase Level and Cerebral Small Vessel Disease.
Lee HB, Kim J, Kim SH, Kim S, Kim OJ, Oh SH.
PLoS One. 2015 Nov 18;10(11):e0143355. doi: 10.1371/journal.pone.0143355. eCollection 2015.

26. Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction
Cho Y, Kim JO, Lee JH, Park HM, Jeon YJ, Oh SH, Bae J, Park YS, Kim OJ, Kim NK.
PLoS One. 2015 Feb 6;10(2):e0115295. doi: 10.1371/journal.pone.0115295. eCollection 2015.

27. Adipose-derived mesenchymal stem cells reduce neuronal death after transient global cerebral ischemia through prevention of blood-brain barrier disruption and endothelial damage.
Chung TN, Kim JH, Choi BY, Chung SP, Kwon SW, Suh SW.
Stem Cells Translational Medicine. 2015; Feb;4(2):178-85

28. 50% duty cycle may be inappropriate to achieve a sufficient chest compression depth when cardiopulmonary resuscitation is performed by female or light rescuers.
Lee CJ, Chung TN*(corresponding author), Bae J, Kim EJ, Choi SW, Kim OJ.
Clin Exp Emerg Med. 2015; Mar 31;2(1):9-15

29. Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice.
Choi BY, Kim JH, Kho AR, Kim IY, Lee SH, Lee BE, Choi E, Sohn M, Stevenson M, Chung TN, Kaupinnen TM, Suh SW.
Journal of Neuroinflammation. 2015; May 28;12:104

30. Rationale and design of the PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage (PICASSO) study: A randomized controlled trial.
Hong KS, Kim BJ, Lee JY, Kwon SU; PICASSO Investigators.
Int J Stroke. 2015 Oct;10(7):1153-8.

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뇌신경계 질환 연구팀

MEMBER

Major Research Fields

Publication