근골격계 질환

근골격계 질환 연구팀

분당차병원의 근골격계 질환 의료진을 중심으로 의생명공학과 연구진과 협력하여 기초와 임상의 시너지 효과를 극대화하고 있으며, 근골격계 질환 세포치료제 원천기술확보에 주력하고 있습니다.
화학적 또는 물리적 자극처리 수술방법을 이용한 근골격계 질환의 다양한 동물모델이 구축되어 있으며, 이러한 동물 모델들을 통해 줄기세포 치료제 또는 생화학적인자/단백질/하이드로젤 복합체 등의 다양한 치료제의 유효성평가가 가능합니다.

MEMBER

상세소개

한인보 교수

· 소속: 신경외과

· 연구분야: 퇴행성 척추 질환 외

상세소개

손세일 교수

· 소속: 신경외과

· 연구분야: 척수 손상 질환 외

상세소개

이순철 교수

· 소속: 정형외과

· 연구분야: 소아 골절 혹은 외상 외

상세소개

민경훈 교수

· 소속: 재활의학과

· 연구분야: 척추손상, 말초신경질환 외

상세소개

한동근 교수

· 소속: 의생명과학과

· 연구분야: 생체재료, 조직재생줄기세포

Major Research Fields

퇴행성 디스크, 척추 유합술, 척수손상, 골다공증
뇌성마비, 외상성 뇌손상 등 중추신경계 손상, 근골격계 질환
골다공증, 골 및 관절 연골 재생
척수손상 동물모델에서 신경보호 기전 규명
척수손상 동물모델에서 줄기세포 이식 치료 효과 규명
척수손상 동물모델에서 비임상유효성 평가
줄기세포공학, 줄기세포를 이용한 조직공학
조직공학, 근골격계 비임상유효성평가

Publication

1. Anti-inflammatory effects of ursodeoxycholic acid by lipopolysaccharide-stimulated inflammatory responses in RAW 264.7 macrophages
Wan-Kyu Ko, Soo-Hong Lee, Sung Jun Kim, Min-Jae Jo, Hemant Kumar, In- Bo Han, Seil Sohn
PLoS ONE. 2017 June 30; 12(6): e0180673.

2. Association of Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphisms with Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.
Kim JO, Han SH, Lee YH, Ahn TK, Lim JJ, Chung YS, Shin DE, Lee WS, Han IB, Kim NK.
Int J Mol Sci. 2016 Dec 9;17(12). pii: E2062.

3. Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury.
Kumar H, Ropper AE, Lee SH, Han I.
Mol Neurobiol. 2017 Jul;54(5):3578-3590. doi: 10.1007/s12035-016-9910-6. Epub 2016 May 18.

4. Association of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.
Lim JJ, Shin DA, Jeon YJ, Kumar H, Sohn S, Min HS, Lee JB, Kuh SU, Kim KN, Kim JO, Kim OJ, Ropper AE, Kim NK, Han IB.
PLoS One. 2016 Jul 25;11(7):e0159756. doi: 10.1371/journal.pone.0159756. eCollection 2016.

5. Guidelines for Dual Energy X-Ray Absorptiometry Analysis of Trabecular Bone-Rich Regions in Mice: Improved Precision, Accuracy, and Sensitivity for Assessing Longitudinal Bone Changes.
Shi J, Lee S, Uyeda M, Tanjaya J, Kim JK, Pan HC, Reese P, Stodieck L, Lin A, Ting K, Kwak JH, Soo C.
Tissue Eng Part C Methods. 2016 May;22(5):451-63. doi: 10.1089/ten.TEC.2015.0383. Epub 2016 Apr 15.

6. Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist.
Lee S, Shen J, Pan HC, Shrestha S, Asatrian G, Nguyen A, Meyers C, Nguyen V, Lee M, Soo C, Ting K, James AW.
Tissue Eng Part A. 2016 Dec;22(23-24):1357-1366. Epub 2016 Oct 18.

7. Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration.
Ashraf S, Cha BH, Kim JS, Ahn J, Han I, Park H, Lee SH.
Osteoarthritis Cartilage. 2016 Feb;24(2):196-205. doi: 10.1016/j.joca.2015.07.008. Epub 2015 Jul 16.

8. Administration of tauroursodeoxycholic acid enhances osteogenic differentiation of bone marrow-derived mesenchymal stem cells and bone regeneration.
Cha BH, Jung MJ, Moon BK, Kim JS, Ma Y, Arai Y, Noh M, Shin JY, Kim BS, Lee SH.
Bone. 2016 Feb;83:73-81. doi: 10.1016/j.bone.2015.10.011. Epub 2015 Oct 21.

9. AIMP1 downregulation restores chondrogenic characteristics of dedifferentiated/degenerated chondrocytes by enhancing TGF-β signal.
Ahn J, Kumar H, Cha BH, Park S, Arai Y, Han I, Park SG, Lee SH.
Cell Death Dis. 2016 Feb 18;7:e2099. doi: 10.1038/cddis.2016.17.

10. Matrilin-3 Role in Cartilage Development and Osteoarthritis.
Muttigi MS, Han I, Park HK, Park H, Lee SH.
See comment in PubMed Commons belowInt J Mol Sci. 2016 Apr 20;17(4). pii: E590. doi: 10.3390/ijms17040590.

11. Enhancement of Matrix Metalloproteinase-2 (MMP-2) as a Potential Chondrogenic Marker during Chondrogenic Differentiation of Human Adipose-Derived Stem Cells.
Arai Y, Park S, Choi B, Ko KW, Choi WC, Lee JM, Han DW, Park HK, Han I, Lee JH, Lee SH.
Int J Mol Sci. 2016 Jun 17;17(6). pii: E963. doi: 10.3390/ijms17060963.

12. Biofunctionalized nanoparticles: an emerging drug delivery platform for various disease treatments.
Bose RJ, Lee SH, Park H.
Drug Discov Today. 2016 Aug;21(8):1303-12. doi: 10.1016/j.drudis.2016.06.005. Epub 2016 Jun 11.

13. Fabrication of FGF-2 immobilized electrospun gelatin nanofibers for tissue engineering.
Lee H, Lim S, Birajdar MS, Lee SH, Park H.
Int J Biol Macromol. 2016 Dec;93(Pt B):1559-1566. doi: 10.1016/j.ijbiomac.2016.07.041. Epub 2016 Jul 15.

14. RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration.
Ashraf S, Ahn J, Cha BH, Kim JS, Han I, Park H, Lee SH.
J Tissue Eng Regen Med. 2017 Sep;11(9):2503-2515. doi: 10.1002/term.2148. Epub 2016 Apr 6.

15. Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury.
Kumar H, Ropper AE, Lee SH, Han I.
Mol Neurobiol. 2017 Jul;54(5):3578-3590. doi: 10.1007/s12035-016-9910-6. Epub 2016 May 18.

16. Guidelines for Dual Energy X-Ray Absorptiometry Analysis of Trabecular Bone-Rich Regions in Mice: Improved Precision, Accuracy, and Sensitivity for Assessing Longitudinal Bone Changes.
Shi J, Lee S, Uyeda M, Tanjaya J, Kim JK, Pan HC, Reese P, Stodieck L, Lin A, Ting K, Kwak JH, Soo C.
Tissue Eng Part C Methods. 2016 May;22(5):451-63. doi: 10.1089/ten.TEC.2015.0383. Epub 2016 Apr 15.

17. Transplantation of human Wharton's jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration.
Ahn J, Park EM, Kim BJ, Kim JS, Choi B, Lee SH, Han I.
Stem Cell Res Ther. 2015 Oct 2;6:190. doi: 10.1186/s13287-015-0183-1.

18. Biological approaches to treating intervertebral disk degeneration: devising stem cell therapies.
Han I, Ropper AE, Konya D, Kabatas S, Toktas Z, Aljuboori Z, Zeng X, Chi JH, Zafonte R, Teng YD.
Cell Transplant. 2015;24(11):2197-208. doi: 10.3727/096368915X688650. Epub 2015 Jul 28.

19. Bone loss of the superior adjacent vertebral body immediately posterior to the anterior flange of Bryan cervical disc.
Kim SH, Chung YS, Ropper AE, Min KH, Ahn TK, Won KS, Shin DA, Han IB.
Eur Spine J. 2015 Dec;24(12):2872-9. doi: 10.1007/s00586-015-3849-6. Epub 2015 Mar 19.

20. Effectiveness of selective peripheral denervation in combination with pallidal deep brain stimulation for the treatment of cervical dystonia.
Chung M, Han I, Chung SS, Jang DK, Huh R.
Acta Neurochir (Wien). 2015 Mar;157(3):435-42. doi: 10.1007/s00701-014-2291-6. Epub 2014 Dec 5.

21. Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy.
Kang M, Min K, Jang J, Kim SC, Kang MS, Jang SJ, Lee JY, Kim SH, Kim MK, An SA, Kim M.
Stem Cells Dev. 2015 Oct 1;24(19):2259-68. doi: 10.1089/scd.2015.0074. Epub 2015 Jul 2.

22. Symptom-Based Treatment of Neuropathic Pain in Spinal Cord-Injured Patients: A Randomized Crossover Clinical Trial.
Min K, Oh Y, Lee SH, Ryu JS.
Am J Phys Med Rehabil. 2016 May;95(5):330-8. doi: 10.1097/PHM.0000000000000382.

23. Brief Report: Human Perivascular Stem Cells and Nel-Like Protein-1 Synergistically Enhance Spinal Fusion in Osteoporotic Rats.
Lee S, Zhang X, Shen J, James AW, Chung CG, Hardy R, Li C, Girgius C, Zhang Y, Stoker D, Wang H, Wu BM, Peault B, Ting K, Soo C.
Stem Cells. 2015 Oct;33(10):3158-63. doi: 10.1002/stem.2103. Epub 2015 Sep 9.

24. Influence of cationic lipid concentration on properties of lipid-polymer hybrid nanospheres for gene delivery.
Bose RJ, Arai Y, Ahn JC, Park H, Lee SH.
Int J Nanomedicine. 2015 Sep 2;10:5367-82. doi: 10.2147/IJN.S87120. eCollection 2015.

25. Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration.
Ashraf S, Cha BH, Kim JS, Ahn J, Han I, Park H, Lee SH.
Osteoarthritis Cartilage. 2016 Feb;24(2):196-205. doi: 10.1016/j.joca.2015.07.008. Epub 2015 Jul 16.

26. Administration of tauroursodeoxycholic acid enhances osteogenic differentiation of bone marrow-derived mesenchymal stem cells and bone regeneration.
Cha BH, Jung MJ, Moon BK, Kim JS, Ma Y, Arai Y, Noh M, Shin JY, Kim BS, Lee SH.
Bone. 2016 Feb;83:73-81. doi: 10.1016/j.bone.2015.10.011. Epub 2015 Oct 21.

27. Stiffness of Hydrogels Regulates Cellular Reprogramming Efficiency Through Mesenchymal-to-Epithelial Transition and Stemness Markers.
Choi B, Park KS, Kim JH, Ko KW, Kim JS, Han DK, Lee SH.
Macromol Biosci. 2016 Feb;16(2):199-206. doi: 10.1002/mabi.201500273. Epub 2015 Oct 6.

28. Transplantation of human Wharton's jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration.
Ahn J, Park EM, Kim BJ, Kim JS, Choi B, Lee SH, Han I.
m Cell Res Ther. 2015 Oct 2;6:190. doi: 10.1186/s13287-015-0183-1.

29. Transplantation of human Wharton's jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration.
Ahn J, Park EM, Kim BJ, Kim JS, Choi B, Lee SH, Han I.
Stem Cell Res Ther. 2015 Oct 2;6:190. doi: 10.1186/s13287-015-0183-1.

30. The Effect of Fetal Bovine Serum (FBS) on Efficacy of Cellular Reprogramming for Induced Pluripotent Stem Cell (iPSC) Generation.
Kwon D, Kim JS, Cha BH, Park KS, Han I, Park KS, Bae H, Han MK, Kim KS, Lee SH.
Cell Transplant. 2016;25(6):1025-42. doi: 10.3727/096368915X689703. Epub 2015 Oct 7.

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핵심인력

근골격계 질환 연구팀

MEMBER

Major Research Fields

Publication