CHA 의과학대학교 분당차병원 임상시험센터

핵심인력

바이오마커 개발 연구팀

바이오마커 개발 연구팀은 각종 암종의 바이오마커 타깃 발굴 및 검증 연구를 수행해 왔으며 최근에는 NGS 의 도입 및 통계분석 전문가를 영입하여 더욱 그 영역을 확대하고 실효성 있는 바이오마커의 발굴에 매진하고 있습니다.
또한 수백개의 다양한 암종의 조직 및 혈액 등 환자 유래물과 각종 organoid 를 보유한 분당차병원의 인체 유래물 은행과 연계하여 수요자 여러분이 원하는 바이오마커 개발을 지원해 드리고자 합니다.

MEMBER

상세소개

김광일 교수

· 소속
병리과
· 연구분야
소화기병리, 간담도병리, 분자병리,
인체 유래물은행장

상세소개

박경순 교수

· 소속
의생명과학과
· 연구분야
종양학, 후생유전학

상세소개

유종만 교수

· 소속
미생물학교실
· 연구분야
오가노이드 연구,
약물재창출 연구

상세소개

황소현 교수

· 소속
의생명과학과
· 연구분야
생물정보학, 통계학

Major Research Fields

  • 난소암 항암표적치료, 암 줄기세포, 바이오마커개발,
    면역세포치료제 개발
  • 인체 유래물은행, Bio-bank 구축 및 분양
  • Bioinformatics, 통계학

Publication

  • 1. Sox10 expression in ovarian epithelial tumors is associated with poor overall survival.

    Virchows Arch. 2016 May;468(5):597-605. doi: 10.1007/s00428-016-1918-9. Epub 2016 Mar 7.

  • 2. ALK gene copy number gain and immunohistochemical expression status using three antibodies in neuroblastoma.

    Kim EK, Kim S.
    Pediatr Dev Pathol. 2016 Mar 17. [Epub ahead of print]

  • 3. Expression patterns of GATA3 and the androgen receptor are strongly correlated in patients with triple-negative breast cancer.

    Kim S, Moon B, Lim W, Park S, Cho MS, Sung SH.
    Hum Pathol. 2016 Sep;55:190-5. doi: 10.1016/j.humpath.2016.04.013. Epub 2016 May 13.

  • 4. Glomerular epithelial CD44 expression and segmental sclerosis in IgA nephropathy.

    Kim S, Kim YH, Choi KH, Jeong H. Clin Exp Nephrol. 2016 Dec;20(6):871-877. Epub 2015 Dec 28.

  • 5. Network-assisted investigation of virulence and antibiotic-resistance systems in Pseudomonas aeruginosa.

    Hwang S, Kim CY, Ji SG, Go J, Kim H, Yang S, Kim HJ, Cho A, Yoon SS, Lee.
    Sci Rep. 2016 May 19;6:26223. doi: 10.1038/srep26223.

  • 6. miR-145, targeting high-mobility group A2, is a powerful predictor of patient outcome in ovarian carcinoma.

    Kim TH, Song JY, Park H, Jeong JY, Kwon AY, Heo JH, Kang H, Kim G, An HJ.
    Cancer Lett. 2015 Jan 28;356(2 Pt B):937-45. doi: 10.1016/j.canlet.2014.11.011. Epub 2014 Nov 10.

  • 7. VAV3 Overexpressed in Cancer Stem Cells Is a Poor Prognostic Indicator in Ovarian Cancer Patients.

    Kwon AY, Kim GI, Jeong JY, Song JY, Kwack KB, Lee C, Kang HY, Kim TH, Heo JH, An HJ.
    Stem Cells Dev. 2015 Jul 1;24(13):1521-35. doi: 10.1089/scd.2014.0588. Epub 2015 Apr 9

  • 8. Hsa-miR-1246 and hsa-miR-1290 are associated with stemness and invasiveness of non-small cell lung cancer.

    Kim G, An HJ, Lee MJ, Song JY, Jeong JY, Lee JH, Jeong HC.
    Lung Cancer. 2016 Jan;91:15-22. doi: 10.1016/j.lungcan.2015.11.013. Epub 2015 Nov 17.

  • 9. Systematic comparison of variant calling pipelines using gold standard personal exome variants.

    Hwang S, Kim E, Lee I, Marcotte EM.
    Sci Rep. 2015 Dec 7;5:17875. doi: 10.1038/srep17875.

  • 10. Dysregulated microRNA expression in adenocarcinoma of the uterine cervix: clinical impact of miR-363-3p.

    Park H, Lee MJ, Jeong JY, Choi MC, Jung SG, Joo WD, Lee C, An HJ.
    Gynecol Oncol. 2014 Dec;135(3):565-72. doi: 10.1016/j.ygyno.2014.09.010. Epub 2014 Sep 16.

  • 11. MTHFR 1298A>C is a risk factor for autism spectrum disorder in the Korean population.

    Park J, Ro M, Pyun JA, Nam M, Bang HJ, Yang JW, Choi KS, Kim SK, Chung JH, Kwack K.
    Psychiatry Res. 2014 Jan 30;215(1):258-9. doi: 10.1016/j.psychres.2013.11.006. Epub 2013 Nov 18.

  • 12. Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

    Chung TN, Kim SW, You JS, Chung HS.
    Stem Cells Dev. 2014 Mar 1;23(5):457-66. doi: 10.1089/scd.2013.0220. Epub 2013 Nov 28.

  • 13. Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells.

    Yoon SW, Kim DK, Kim KP, Park KS.
    Stem Cells Dev. 2014 Nov 15;23(22):2700-11. doi: 10.1089/scd.2014.0129. Epub 2014 Aug 18.

  • 14. Hydroxyurea induces a hypersensitive apoptotic response in mouse embryonic stem cells through p38-dependent acetylation of p53.

    Heo SH, Cha Y, Park KS.
    Stem Cells Dev. 2014 Oct 15;23(20):2435-42. doi: 10.1089/scd.2013.0608. Epub 2014 Jul 1.

  • 15. Overexpression of goosecoid homeobox is associated with chemoresistance and poor prognosis in ovarian carcinoma.

    Kang KW, Lee MJ, Song JA, Jeong JY, Kim YK, Lee C, Kim TH, Kwak KB, Kim OJ, An H.
    Oncol Rep. 2014 Jul;32(1):189-98. doi: 10.3892/or.2014.3203. Epub 2014 May 20.

  • 16. MORPHIN: a web tool for human disease research by projecting model organism biology onto a human integrated gene network.

    Hwang S, Kim E, Yang S, Marcotte EM, Lee I.
    Nucleic Acids Res. 2014 Jul;42(Web Server issue):W147-53. doi: 10.1093/nar/gku434. Epub 2014 May 26.

  • 17. Diplotyper: diplotype-based association analysis.

    Kim S, Park K, Shin C, Cho NH, Ko JJ, Koh I, Kwack K.
    BMC Med Genomics. 2013;6 Suppl 2:S5. doi: 10.1186/1755-8794-6-S2-S5. Epub 2013 May 7.

  • 18. Associations between single-nucleotide polymorphism in the FNDC3A and autism spectrum disorder in a Korean population.

    18. Associations between single-nucleotide polymorphism in the FNDC3A and autism spectrum disorder in a Korean population. Ro M, Park J, Nam M, Bang HJ, Yang JW, Choi KS, Kim SK, Chung JH, Kwack K.
    Psychiatry Res. 2013 Sep 30;209(2):246-8. doi: 10.1016/j.psychres.2013.02.028. Epub 2013 Apr 29.

  • 19. Association of the FGA and SLC6A4 genes with autistic spectrum disorder in a Korean population.

    Ro M, Won S, Kang H, Kim SY, Lee SK, Nam M, Bang HJ, Yang JW, Choi KS, Kim SK, Chung JH, Kwack K.
    Neuropsychobiology. 2013;68(4):212-20. doi: 10.1159/000355299. Epub 2013 Nov 1.
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